What is 7-OHM? [Lab Report]
7-Hydroxymitragynine is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as Kratom. It is often referred to as ‘7-OHM’. It was first described in 1994 and is a natural product derived from the mitragynine present in the Kratom leaf. It is considered an oxidized derivative and active metabolite of mitragynine. 7-OHM binds to opioid receptors like mitragynine, but research suggests that 7-OHM binds with greater potency and contributes heavily to the analgesic activity of mitragynine as a metabolite.

What are the effects?
7-Hydroxymitragynine (7-OHM), like mitragynine, is a mixed opioid receptor agonist/antagonist, acting as a partial agonist at µ-opioid receptors which causes euphoria and as a competitive antagonist at δ- and κ-opioid receptors which is possibly attributed to its stimulating effects at low dosages. 7-OHM does not activate the β-arrestin pathway like traditional opioids, meaning symptoms such as respiratory depression, constipation and sedation are much less pronounced. In simple terms 7-OHM is a euphoric stimulant at low doses and becomes more sedative at high doses.

With over 20 active alkaloids present in Mitragyna Speciosa (Kratom), we are the only laboratory in the world able to naturally extract and preserve at scale, the most sought after alkaloid present in the Kratom plant: 7-hydroxymitragynine (7OHM), leaving behind the other minor alkaloids.